Which of the following is not an indication for pseudocyst drainage?

The indication for pseudocyst drainage typically includes several clinical scenarios. Enlargement over time suggests that the pseudocyst may be unstable and potentially causing further complications, which warrants drainage. Pain associated with a pseudocyst is a common indication for intervention, as it significantly impacts the patient's quality of life. Biliary obstruction can occur due to the mass effect of the pseudocyst, leading to further complications if not addressed, thereby justifying drainage.

On the other hand, while a size greater than 3 cm is often considered in clinical practice, it does not automatically indicate the need for drainage. A pseudocyst of this size may remain asymptomatic and stable without necessitating intervention. Thus, size alone does not serve as a definitive indication for drainage, making this the correct choice in the context of the question.