Elevated bilirubin may indicate a problem with which of the following organs?

Elevated bilirubin levels are primarily associated with liver function and health. Bilirubin is a byproduct of the breakdown of hemoglobin in red blood cells and is processed by the liver. When the liver is functioning properly, it converts bilirubin into a form that can be excreted in bile and urine. If there are issues with the liver, such as liver disease, obstruction of bile ducts, or conditions affecting liver cell function, bilirubin can accumulate in the bloodstream, leading to elevated levels.

This is often seen in conditions such as hepatitis, cirrhosis, or bile duct obstruction. The increased bilirubin can cause jaundice, which is the yellowing of the skin and eyes, a classic sign of liver dysfunction.

While the heart, large intestine, and pancreas have important roles in overall health, they are not directly associated with the metabolism and excretion of bilirubin. Therefore, when interpreting elevated bilirubin levels, the liver is the organ that should be examined for potential issues.